M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice

In T-cell–dependent antibody responses, antigen-specific B cells undergo a phase of secondary antibody diversification in germinal centers (GCs). Somatic hypermutation (SHM) introduces mutations into the rearranged immunoglobulin (Ig) variable (V) region genes, and class-switch recombination (CSR) a...

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Bibliographic Details
Main Authors: Schenten, Dominik, Egert, Angela, Pasparakis, Manolis, Rajewsky, Klaus
Format: Artigo
Language:Inglês
Published: The American Society of Hematology 2006
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895815/
https://ncbi.nlm.nih.gov/pubmed/16493007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-10-4154
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