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Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability
Polζ is an error-prone DNA polymerase that is critical for embryonic development and maintenance of genome stability. To analyze its suggested role in somatic hypermutation (SHM) and possible contribution to DNA double-strand break (DSB) repair in class switch recombination (CSR), we ablated Rev3, t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646585/ https://ncbi.nlm.nih.gov/pubmed/19204108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080669 |
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