Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance

Oncogenic RAS expression occurs in up to 40% of multiple myeloma (MM) cases and correlates with aggressive disease. Since activated RAS induces cyclooxygenase-2 (cox-2) expression in other tumor models, we tested a role for cox-2 in mutant RAS–containing MM cells. We used the ANBL-6 isogenic MM cell...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hoang, Bao, Zhu, Li, Shi, Yijiang, Frost, Patrick, Yan, Huajun, Sharma, Sanjai, Sharma, Sherven, Goodglick, Lee, Dubinett, Steven, Lichtenstein, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895799/
https://ncbi.nlm.nih.gov/pubmed/16497971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-09-3926
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados