Intratumoral CD4(+)CD25(+) regulatory T-cell-mediated suppression of infiltrating CD4(+) T cells in B-cell non-Hodgkin lymphoma

Most non-Hodgkin lymphomas (NHLs) are of B-cell origin, but the tumor tissue can be variably infiltrated with T cells. In the present study, we have identified a subset of CD4(+)CD25(+) T cells with high levels of CTLA-4 and Foxp3 (intratumoral T(reg) cells) that are overrepresented in biopsy specim...

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Hlavní autoři: Yang, Zhi-Zhang, Novak, Anne J., Stenson, Mary J., Witzig, Thomas E., Ansell, Stephen M.
Médium: Artigo
Jazyk:Inglês
Vydáno: © 2006 by The American Society of Hematology 2006
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895773/
https://ncbi.nlm.nih.gov/pubmed/16403912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3376
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