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A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse β-globin locus

Developmental expression at the β-globin locus is regulated in part by the locus control region, a region upstream of the genes containing at least five major DNase I hypersensitive sites (HSs) in mammalian erythrocytes. Sequences farther 5′ of these HSs are conserved in mouse and human, and both lo...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Farrell, Catherine M., Grinberg, Alexander, Huang, Sing Ping, Chen, Dan, Pichel, José G., Westphal, Heiner, Felsenfeld, Gary
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18957/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11121056/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.26.14554
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