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A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse β-globin locus

Developmental expression at the β-globin locus is regulated in part by the locus control region, a region upstream of the genes containing at least five major DNase I hypersensitive sites (HSs) in mammalian erythrocytes. Sequences farther 5′ of these HSs are conserved in mouse and human, and both lo...

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Κύριοι συγγραφείς: Farrell, Catherine M., Grinberg, Alexander, Huang, Sing Ping, Chen, Dan, Pichel, José G., Westphal, Heiner, Felsenfeld, Gary
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The National Academy of Sciences 2000
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC18957/
https://ncbi.nlm.nih.gov/pubmed/11121056
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