Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK(+) anaplastic large-cell lymphoma cells

The aberrant fusion protein NPM-ALK plays an important pathogenetic role in ALK(+) anaplastic large-cell lymphoma (ALCL). We previously demonstrated that Jak3 potentiates the activity of NPM-ALK. Jak3 activation is restricted to interleukins that recruit the common γ chain (γc) receptor, including I...

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Detalhes bibliográficos
Main Authors: Qiu, Lin, Lai, Raymond, Lin, Quan, Lau, Esther, Thomazy, David M., Calame, Daniel, Ford, Richard J., Kwak, Larry W., Kirken, Robert A., Amin, Hesham M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895569/
https://ncbi.nlm.nih.gov/pubmed/16763206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-020305
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