Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)–based mutagenesis screen: high efficacy of drug combinations

BMS-354825 (dasatinib) and AMN107 (nilotinib) are potent alternate Abl inhibitors with activity against many imatinib mesylate–resistant BCR-ABL kinase domain (KD) mutants, except T315I. We used N-ethyl-N-nitrosourea (ENU)–exposed Ba/F3-p210(BCR-ABL) cells to compare incidence and types of KD mutant...

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Detalhes bibliográficos
Main Authors: Bradeen, Heather A., Eide, Christopher A., O'Hare, Thomas, Johnson, Kara J., Willis, Stephanie G., Lee, Francis Y., Druker, Brian J., Deininger, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895563/
https://ncbi.nlm.nih.gov/pubmed/16772610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-02-004580
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