Trans-presentation of donor-derived interleukin 15 is necessary for the rapid onset of acute graft-versus-host disease but not for graft-versus-tumor activity

The “holy grail” of allogeneic stem cell transplantation is to preserve the graft-versus-tumor (GVT) effect while eliminating graft-versus-host disease (GVHD). Endogenous donor-derived interleukin 15 (IL-15) has been implicated in the pathogenesis of acute GVHD, yet the mechanism by which it impacts...

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Autori principali: Blaser, Bradley W., Schwind, Noah R., Karol, Seth, Chang, Dennis, Shin, Samuel, Roychowdhury, Sameek, Becknell, Brian, Ferketich, Amy K., Kusewitt, Donna F., Blazar, Bruce R., Caligiuri, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2006
Soggetti:
Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895554/
https://ncbi.nlm.nih.gov/pubmed/16757683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-019059
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