IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease

Interleukin-2 (IL-2) and IL-15 are structurally related cytokines that share receptor components but display markedly different effects in multiple in vivo model systems. Here we demonstrate that IL-15 but not IL-2 exacerbates xenogeneic graft-versus-host disease (X-GVHD) in severe combined immunode...

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Bibliografiske detaljer
Main Authors: Roychowdhury, Sameek, Blaser, Bradley W., Freud, Aharon G., Katz, Kerry, Bhatt, Darshna, Ferketich, Amy K., Bergdall, Valerie, Kusewitt, Donna, Baiocchi, Robert A., Caligiuri, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2005
Fag:
Immunobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895258/
https://ncbi.nlm.nih.gov/pubmed/15976176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1597
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