Somatic activation of a conditional Kras(G12D) allele causes ineffective erythropoiesis in vivo

Somatic activation of a conditional targeted Kras(G12D) allele induces a fatal myeloproliferative disease in mice that closely models juvenile and chronic myelomonocytic leukemia. These mice consistently develop severe and progressive anemia despite adequate numbers of clonogenic erythroid progenito...

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Detalhes bibliográficos
Main Authors: Braun, Benjamin S., Archard, Joehleen A., Van Ziffle, Jessica A. G., Tuveson, David A., Jacks, Tyler E., Shannon, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895533/
https://ncbi.nlm.nih.gov/pubmed/16720837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-013490
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