IL-2 regulates FOXP3 expression in human CD4(+)CD25(+) regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

IL-2 plays a critical role in the maintenance of CD4(+)CD25(+) FOXP3(+) regulatory T cells (Tregs) in vivo. We examined the effects of IL-2 signaling in human Tregs. In vitro, IL-2 selectively up-regulated the expression of FOXP3 in purified CD4(+)CD25(+) T cells but not in CD4(+)CD25(-) cells. This...

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Hauptverfasser: Zorn, Emmanuel, Nelson, Erik A., Mohseni, Mehrdad, Porcheray, Fabrice, Kim, Haesook, Litsa, Despina, Bellucci, Roberto, Raderschall, Elke, Canning, Christine, Soiffer, Robert J., Frank, David A., Ritz, Jerome
Format: Artigo
Sprache:Inglês
Veröffentlicht: © 2006 by The American Society of Hematology 2006
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895505/
https://ncbi.nlm.nih.gov/pubmed/16645171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-02-004747
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