Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity

The prognosis for patients with mantle cell lymphoma (MCL) is poor, and at present there is no truly effective therapy. Gene translocation-mediated constitutive expression of cyclin D1 seems to play the key role in the pathogenesis of MCL. Here we report that although 3 of 4 MCL cell lines expressed...

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Detalhes bibliográficos
Main Authors: Marzec, Michal, Kasprzycka, Monika, Lai, Raymond, Gladden, Andrew B., Wlodarski, Pawel, Tomczak, Ewa, Nowell, Peter, DePrimo, Samuel E., Sadis, Seth, Eck, Stephen, Schuster, Stephen J., Diehl, J. Alan, Wasik, Mariusz A.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895502/
https://ncbi.nlm.nih.gov/pubmed/16690963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-016634
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