Absence of β7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine

The α4β7 integrin plays a central role in the homing of T cells to the gut. We hypothesized that absence of the β7 subunit would result in a reduction of intestinal graft-versus-host disease (GVHD) and an improvement in overall GVHD morbidity and mortality in recipients of hematopoietic stem cell tr...

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Hlavní autoři: Waldman, Elisha, Lu, Sydney X., Hubbard, Vanessa M., Kochman, Adam A., Eng, Jeffrey M., Terwey, Theis H., Muriglan, Stephanie J., Kim, Theo D., Heller, Glenn, Murphy, George F., Liu, Chen, Alpdogan, Onder, van den Brink, Marcel R. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: © 2006 by The American Society of Hematology 2006
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895413/
https://ncbi.nlm.nih.gov/pubmed/16291587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3445
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