Nitric oxide and cGMP protein kinase (cGK) regulate dendritic-cell migration toward the lymph-node–directing chemokine CCL19

Dendritic-cell (DC) migration to secondary lymphoid organs is crucial for the initiation of adaptive immune responses. Although LPS up-regulates CCR7 on DCs, a second signal is required to enable them to migrate toward the chemokine CCL19 (MIP-3β). We found that the nitric oxide (NO) donor NOR4 prov...

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Detalles Bibliográficos
Main Authors: Giordano, Daniela, Magaletti, Dario M., Clark, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado: © 2006 by The American Society of Hematology 2006
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895400/
https://ncbi.nlm.nih.gov/pubmed/16249377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-07-2901
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