In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity

Bone marrow-derived antigen-presenting cells (APCs) play a central role in the induction of tolerance to tumor antigens expressed by B-cell lymphomas. Here we show that in vivo disruption of this APC-mediated tolerogenic mechanism unveils an intrinsic ability of malignant B cells to efficiently pres...

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Detalhes bibliográficos
Main Authors: Horna, Pedro, Cuenca, Alex, Cheng, Fengdong, Brayer, Jason, Wang, Hong-Wei, Borrello, Ivan, Levitsky, Hyam, Sotomayor, Eduardo M.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895389/
https://ncbi.nlm.nih.gov/pubmed/16339406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-07-3014
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