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Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP

Thrombin-mediated endothelial-cell release of von Willebrand factor (VWF) and P-selectin functionally links protease-activated receptors (PARs) to thrombosis and inflammation. VWF release can be stimulated by both Ca(2+) and cAMP, and, although both VWF and P-selectin are found in Weibel-Palade bodi...

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Autori principali: Cleator, John H., Zhu, Wen Qin, Vaughan, Douglas E., Hamm, Heidi E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895372/
https://ncbi.nlm.nih.gov/pubmed/16332977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-07-2698
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