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Total body irradiation selectively induces murine hematopoietic stem cell senescence
Exposure to ionizing radiation (IR) and certain chemotherapeutic agents not only causes acute bone marrow (BM) suppression but also leads to long-term residual hematopoietic injury. This latter effect has been attributed to damage to hematopoietic stem cell (HSC) self-renewal. Using a mouse model, w...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
© 2006 by The American Society of Hematology
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895367/ https://ncbi.nlm.nih.gov/pubmed/16150936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1418 |
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