Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia

Shp2 tyrosine phosphatase plays a critical role in hematopoiesis, and dominant active mutations have been detected in the human gene PTPN11, encoding Shp2, in child leukemia patients. We report here that although no such mutations were detected in 44 adult leukemia patients screened, Shp2 expression...

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Autors principals: Xu, Rongzhen, Yu, Yingzi, Zheng, Shu, Zhao, Xiaoying, Dong, Qinghua, He, Zhiwen, Liang, Yun, Lu, Qinghua, Fang, Yongmin, Gan, Xiaoxian, Xu, Xiaohua, Zhang, Suzhan, Dong, Qi, Zhang, Xiaohong, Feng, Gen-Sheng
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2005
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895328/
https://ncbi.nlm.nih.gov/pubmed/16030196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-10-4057
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