Tachpyridine, a metal chelator, induces G(2) cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation

Iron is critical for cell growth and proliferation. Iron chelators are being explored for a number of clinical applications, including the treatment of neurodegenerative disorders, heart disease, and cancer. To uncover mechanisms of action of tachpyridine, a chelator currently undergoing preclinical...

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Autori principali: Turner, JoLyn, Koumenis, Constantinos, Kute, Timothy E., Planalp, Roy P., Brechbiel, Martin W., Beardsley, Dillon, Cody, Brooke, Brown, Kevin D., Torti, Frank M., Torti, Suzy V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: © 2005 by The American Society of Hematology 2005
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895322/
https://ncbi.nlm.nih.gov/pubmed/16014567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1263
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