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Tachpyridine, a metal chelator, induces G(2) cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation
Iron is critical for cell growth and proliferation. Iron chelators are being explored for a number of clinical applications, including the treatment of neurodegenerative disorders, heart disease, and cancer. To uncover mechanisms of action of tachpyridine, a chelator currently undergoing preclinical...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
© 2005 by The American Society of Hematology
2005
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895322/ https://ncbi.nlm.nih.gov/pubmed/16014567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1263 |
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