Mitochondrial DNA spectra of single human CD34(+) cells, T cells, B cells, and granulocytes

Previously, we described the age-dependent accumulation of mitochondrial DNA (mtDNA) mutations, leading to a high degree of mtDNA heterogeneity among normal marrow and blood CD34(+) clones and in granulocytes. We established a method for sequence analysis of single cells. We show marked, distinct mt...

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Detalhes bibliográficos
Main Authors: Ogasawara, Yoji, Nakayama, Kazutaka, Tarnowka, Magdalena, McCoy, J. Philip, Kajigaya, Sachiko, Levin, Barbara C., Young, Neal S.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Stem Cells in Hematology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895318/
https://ncbi.nlm.nih.gov/pubmed/16020515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-01-0150
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