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Mitochondrial DNA sequence variation in single cells from leukemia patients

A high frequency of mtDNA somatic mutation has been observed in many tumors as well as in aging tissues. In this study, we analyzed the mtDNA control region sequence variation in 3534 single normal cells and individual blasts from 18 patients with leukemia and 10 healthy donors, to address the mutat...

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Detalhes bibliográficos
Main Authors: Yao, Yong-Gang, Ogasawara, Yoji, Kajigaya, Sachiko, Molldrem, Jeffrey J., Falcão, Roberto P., Pintão, Maria-Carolina, McCoy, J. Philip, Rizzatti, Edgar Gil, Young, Neal S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785100/
https://ncbi.nlm.nih.gov/pubmed/16946307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-011007
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