Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

The PU.1 transcription factor is a key regulator of hematopoietic development, but its role at each hematopoietic stage remains unclear. In particular, the expression of PU.1 in hematopoietic stem cells (HSCs) could simply represent “priming” of genes related to downstream myelolymphoid lineages. By...

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Bibliografiske detaljer
Main Authors: Iwasaki, Hiromi, Somoza, Chamorro, Shigematsu, Hirokazu, Duprez, Estelle A., Iwasaki-Arai, Junko, Mizuno, Shin-ichi, Arinobu, Yojiro, Geary, Kristin, Zhang, Pu, Dayaram, Tajhal, Fenyus, Maris L., Elf, Shannon, Chan, Susan, Kastner, Philippe, Huettner, Claudia S., Murray, Richard, Tenen, Daniel G., Akashi, Koichi
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2005
Fag:
Hematopoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895212/
https://ncbi.nlm.nih.gov/pubmed/15914556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-0860
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