The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell–expressed S1P(1) amplifies integrin activation in peripheral lymph nodes but not in Peyer patches

Sphingosine-1-phosphate (S1P) and its receptor S1P(1) control T-cell egress from thymus and secondary lymphoid organs (SLOs). To further define the role of S1P(1) in lymphocyte trafficking, we performed adoptive transfer experiments and intravital microscopy (IVM) using both S1P(1)(–/–) lymphocytes...

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Autori principali: Halin, Cornelia, Scimone, M. Lucila, Bonasio, Roberto, Gauguet, Jean-Marc, Mempel, Thorsten R., Quackenbush, Elizabeth, Proia, Richard L., Mandala, Suzanne, von Andrian, Ulrich H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2005
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895188/
https://ncbi.nlm.nih.gov/pubmed/15870184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-09-3687
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