Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

The homeobox gene Hoxa-9 is normally expressed in primitive bone marrow cells, and overexpression of Hoxa-9 markedly expands hematopoietic stem cells, suggesting a function in early hematopoiesis. We present evidence for major functional defects in Hoxa-9(-)(/)(-) hematopoietic stem cells. Hoxa-9(-)...

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Autors principals: Lawrence, H. Jeffrey, Christensen, Julie, Fong, Stephen, Hu, Yu-Long, Weissman, Irving, Sauvageau, Guy, Humphries, R. Keith, Largman, Corey
Format: Artigo
Idioma:Inglês
Publicat: © 2005 by The American Society of Hematology 2005
Matèries:
Stem Cells in Hematology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895111/
https://ncbi.nlm.nih.gov/pubmed/16091451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-2003
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