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Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells
The homeobox gene Hoxa-9 is normally expressed in primitive bone marrow cells, and overexpression of Hoxa-9 markedly expands hematopoietic stem cells, suggesting a function in early hematopoiesis. We present evidence for major functional defects in Hoxa-9(-)(/)(-) hematopoietic stem cells. Hoxa-9(-)...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
© 2005 by The American Society of Hematology
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895111/ https://ncbi.nlm.nih.gov/pubmed/16091451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-2003 |
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