Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1α

Thrombopoietin (TPO), the primary regulator of thrombopoiesis, is also an important, nonredundant mediator of hematopoietic stem cell (HSC) development. For example, following transplantation, HSC expansion is approximately 15-fold more robust in normal than in Tpo(-/-) mice. Vascular endothelial gr...

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Autores principales: Kirito, Keita, Fox, Norma, Komatsu, Norio, Kaushansky, Kenneth
Formato: Artigo
Lenguaje:Inglês
Publicado: © 2005 by The American Society of Hematology 2005
Materias:
Hematopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895043/
https://ncbi.nlm.nih.gov/pubmed/15705785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-07-2712
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