Reprogramming Human Endothelial to Hematopoietic Cells Requires Vascular Induction

Generating engraftable human hematopoietic cells from autologous tissues promises new therapies for blood diseases. Directed differentiation of pluripotent stem cells yields hematopoietic cells that poorly engraft. Here, we devised a method to phenocopy the vascular-niche microenvironment of hemogen...

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Hauptverfasser: Sandler, Vladislav M., Lis, Raphael, Liu, Ying, Kedem, Alon, James, Daylon, Elemento, Olivier, Butler, Jason M., Scandura, Joseph M., Rafii, Shahin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159670/
https://ncbi.nlm.nih.gov/pubmed/25030167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13547
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