Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia

Interaction between target cell CD47 and the inhibitory macrophage receptor signal regulatory protein α (SIRPα) counteracts macrophage phagocytosis of CD47-expressing host cells. As platelets also express CD47, we asked whether inhibitory CD47/SIRPα signaling regulates normal platelet turnover and c...

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Autori principali: Olsson, Mattias, Bruhns, Pierre, Frazier, William A., Ravetch, Jeffrey V., Oldenborg, Per-Arne
Natura: Artigo
Lingua:Inglês
Pubblicazione: © 2005 by The American Society of Hematology 2005
Soggetti:
Hemostasis, Thrombosis, and Vascular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895021/
https://ncbi.nlm.nih.gov/pubmed/15665111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-2980
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