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Depletion of newly synthesized Argonaute1 impairs the RNAi response in Trypanosoma brucei

In Trypanosoma brucei, Argonaute1 (TbAGO1) is an essential component of the RNA interference (RNAi) pathway. While characterizing a TbAGO1 conditional knockout cell line, we discovered that, upon blockage of TbAGO1 transcription, the RNAi response to transfected double-stranded RNA was severely inhi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shi, Huafang, Tschudi, Christian, Ullu, Elisabetta
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894921/
https://ncbi.nlm.nih.gov/pubmed/17526643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.474707
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