A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology

AIMS: The objective of this study was to evaluate the potential uses of relative abundance, relative activity approaches and inhibitory monoclonal antibodies (mAbs) in the characterization of CYP enzymology in early drug discovery. METHODS: Intrinsic clearance estimates for the oxidation of ethoxyre...

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Hauptverfasser: Soars, Matthew G, Gelboin, Harry V, Krausz, Kristopher W, Riley, Robert J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2003
Schlagworte:
Drug Disposition
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894739/
https://ncbi.nlm.nih.gov/pubmed/12580989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01721.x
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