Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10

IL10 is a powerful TH-2 cell cytokine produced by lymphoid cells that limits HIV-1 replication in vivo, ostensibly by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of inflammatory cytokines (IL1, TNFα, IL6, IL8, and IL12). A genetic epidemiological scan of patients e...

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Detalhes bibliográficos
Main Authors: Shin, Hyoung Doo, Winkler, Cheryl, Stephens, J. Claiborne, Bream, Jay, Young, Howard, Goedert, James J., O'Brien, Thomas R., Vlahov, David, Buchbinder, Susan, Giorgi, Janis, Rinaldo, Charles, Donfield, Sharyne, Willoughby, Anne, O'Brien, Stephen J., Smith, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18942/
https://ncbi.nlm.nih.gov/pubmed/11121048
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