Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10

IL10 is a powerful TH-2 cell cytokine produced by lymphoid cells that limits HIV-1 replication in vivo, ostensibly by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of inflammatory cytokines (IL1, TNFα, IL6, IL8, and IL12). A genetic epidemiological scan of patients e...

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Hauptverfasser: Shin, Hyoung Doo, Winkler, Cheryl, Stephens, J. Claiborne, Bream, Jay, Young, Howard, Goedert, James J., O'Brien, Thomas R., Vlahov, David, Buchbinder, Susan, Giorgi, Janis, Rinaldo, Charles, Donfield, Sharyne, Willoughby, Anne, O'Brien, Stephen J., Smith, Michael W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18942/
https://ncbi.nlm.nih.gov/pubmed/11121048
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