Polymorphisms of CUL5 Are Associated with CD4(+) T Cell Loss in HIV-1 Infected Individuals

Human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (Apobec3) antiretroviral factors cause hypermutation of proviral DNA leading to degradation or replication-incompetent HIV-1. However, HIV-1 viral infectivity factor (Vif) suppresses Apobec3 activity through the Cullin 5-Elongi...

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Main Authors: An, Ping, Duggal, Priya, Wang, Li Hua, O'Brien, Stephen J, Donfield, Sharyne, Goedert, James J, Phair, John, Buchbinder, Susan, Kirk, Gregory D, Winkler, Cheryl A
格式: Artigo
語言:Inglês
出版: Public Library of Science 2007
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1781497/
https://ncbi.nlm.nih.gov/pubmed/17257057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030019
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