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Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance

The immune response is critical in determining the outcome of hepatitis C virus (HCV) infection. Interleukin (IL)-18 is a pivotal mediator of Th1/Th2 driven immune response. Two IL-18 promoter polymorphisms (-607 C/A and -137 G/C) and their haplotypes were known to affect the IL-18 expression. We ex...

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Bibliografiska uppgifter
Huvudupphovsmän: An, Ping, Thio, Chloe L., Kirk, Gregory D., Donfield, Sharyne, Goedert, James J., Winkler, Cheryl A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674361/
https://ncbi.nlm.nih.gov/pubmed/18781864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/592047
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