A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients.

Current knowledge of hepatitis B virus (HBV) sequence heterogeneity is based mainly on sequencing of amplified subgenomic HBV fragments. Here, we describe a method which allows sensitive amplification and simplified functional analysis of full-length HBV genomes with or without prior cloning. By thi...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Günther, S, Li, B C, Miska, S, Krüger, D H, Meisel, H, Will, H
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189390/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7636989/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.9.5437-5444.1995
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