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Thermodynamic analysis of progesterone receptor–promoter interactions reveals a molecular model for isoform-specific function

Human progesterone receptors (PR) exist as two functionally distinct isoforms, PR-A and PR-B. The proteins are identical except for an additional 164 residues located at the N terminus of PR-B. To determine the mechanisms responsible for isoform-specific functional differences, we present here a the...

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Detalhes bibliográficos
Main Authors: Connaghan-Jones, Keith D., Heneghan, Aaron F., Miura, Michael T., Bain, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892943/
https://ncbi.nlm.nih.gov/pubmed/17277083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608848104
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