Interference with Transforming Growth Factor-β/ Smad3 Signaling Results in Accelerated Healing of Wounds in Previously Irradiated Skin

Transforming growth factor (TGF)-β regulates many aspects of wound repair including inflammation, chemotaxis, and deposition of extracellular matrix. We previously showed that epithelialization of incisional wounds is accelerated in mice null for Smad3, a key cytoplasmic mediator of TGF-β signaling....

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Detalhes bibliográficos
Principais autores: Flanders, Kathleen C., Major, Christopher D., Arabshahi, Alidad, Aburime, Ekinadese E., Okada, Miya H., Fujii, Makiko, Blalock, Timothy D., Schultz, Gregory S., Sowers, Anastasia, Anzano, Mario A., Mitchell, James B., Russo, Angelo, Roberts, Anita B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892357/
https://ncbi.nlm.nih.gov/pubmed/14633599
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