Cyclooxygenase-2 Deficiency Results in a Loss of the Anti-Proliferative Response to Transforming Growth Factor-β in Human Fibrotic Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice

Prostaglandin E(2) (PGE(2)) inhibits fibroblast proliferation and collagen production. Its synthesis by fibroblasts is induced by profibrotic mediators including transforming growth factor (TGF)-β(1). However, in patients with pulmonary fibrosis, PGE(2) levels are decreased. In this study we examine...

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Autors principals: Keerthisingam, Carmel B., Jenkins, R. Gisli, Harrison, Nicholas K., Hernandez-Rodriguez, Norma A., Booth, Helen, Laurent, Geoffrey J., Hart, Stephen L., Foster, Martyn L., McAnulty, Robin J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2001
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891895/
https://ncbi.nlm.nih.gov/pubmed/11290559
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