Severity of Lung Injury in Cyclooxygenase-2-Deficient Mice Is Dependent on Reduced Prostaglandin E(2) Production

Levels of prostaglandin E(2) (PGE(2)), a potent inhibitor of fibroblast function, are decreased in the lungs of patients with pulmonary fibrosis, which has been shown to be because of limited expression of cyclooxygenase-2 (COX-2). To further investigate the relative importance of COX-2 and PGE(2) i...

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Main Authors: Hodges, Rebecca J., Jenkins, R. Gisli, Wheeler-Jones, Caroline P.D., Copeman, Danielle M., Bottoms, Stephen E., Bellingan, Geoffrey J., Nanthakumar, Carmel B., Laurent, Geoffrey J., Hart, Stephen L., Foster, Martyn L., McAnulty, Robin J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2004
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Original Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618657/
https://ncbi.nlm.nih.gov/pubmed/15509536
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