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Excluded volume, local structural cooperativity, and the polymer physics of protein folding rates

A coarse-grained variational model is used to investigate the polymer dynamics of barrier crossing for a diverse set of two-state folding proteins. The model gives reliable folding rate predictions provided excluded volume terms that induce minor structural cooperativity are included in the interact...

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Bibliografske podrobnosti
Main Authors: Qi, Xianghong, Portman, John J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891811/
https://ncbi.nlm.nih.gov/pubmed/17569785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609321104
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