Reprogramming leukemic cells to terminal differentiation by inhibiting specific cyclin-dependent kinases in G(1)

Some tumor cells can be stimulated to differentiate and undergo terminal cell division and loss of tumorigenicity. The in vitro differentiation of murine erythroleukemia (MEL) cells is a dramatic example of tumor-cell reprogramming. We found that reentry of MEL cells into terminal differentiation is...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Matushansky, Igor, Radparvar, Farshid, Skoultchi, Arthur I.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18916/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11114185/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.250488697
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