Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [(3)H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall

Daptomycin monotherapy was superior to ceftriaxone monotherapy and was highly efficacious in experimental pneumococcal meningitis, sterilizing the cerebrospinal fluid (CSF) of three of three rabbits after 4 to 6 h. With daptomycin therapy only a negligible release of [(3)H]choline as marker of cell...

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Autori principali: Stucki, A., Cottagnoud, M., Winkelmann, V., Schaffner, T., Cottagnoud, P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891375/
https://ncbi.nlm.nih.gov/pubmed/17371817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01000-06
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