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Cyclin D–Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization

Endomitosis is a unique form of cell cycle used by megakaryocytes, in which the latter stages of mitosis are bypassed so that the cell can increase its DNA content and size. Although several transcription factors, including GATA-1 and RUNX-1, have been implicated in this process, the link between tr...

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Détails bibliographiques
Auteurs principaux: Muntean, Andrew G., Pang, Liyan, Poncz, Mortimer, Dowdy, Steven F., Blobel, Gerd A., Crispino, John D.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890844/
https://ncbi.nlm.nih.gov/pubmed/17317855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-11-059378
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