Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells

Increased levels of Bcr-Abl expression in chronic myelogenous leukemia (CML) cells are associated with disease progression and imatinib (IM) resistance. However, it is not clear if these associations are a direct result of elevated Bcr-Abl expression. We used a human transduction model of CML to dir...

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Hlavní autoři: Modi, Hardik, McDonald, Tinisha, Chu, Su, Yee, Jiing-Kuan, Forman, Stephen J., Bhatia, Ravi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890842/
https://ncbi.nlm.nih.gov/pubmed/17347407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-032490
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