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The helix–turn–helix motif as an ultrafast independently folding domain: The pathway of folding of Engrailed homeodomain

Helices 2 and 3 of Engrailed homeodomain (EnHD) form a helix–turn–helix (HTH) motif. This common motif is believed not to fold independently, which is the characteristic feature of a motif rather than a domain. But we found that the EnHD HTH motif is monomeric and folded in solution, having essentia...

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書誌詳細
主要な著者: Religa, Tomasz L., Johnson, Christopher M., Vu, Dung M., Brewer, Scott H., Dyer, R. Brian, Fersht, Alan R.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890484/
https://ncbi.nlm.nih.gov/pubmed/17517666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703434104
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