Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer

Resistance to camptothecin (CPT), a topoisomerase I (Top1) inhibitor, is frequently encountered in non-small cell lung cancer (NSCLC) and CPT resistance is linked with TDP1, an enzyme capable of cleaving the covalent linkage between stabilized Top1 with DNA. The aim of this study is to evaluate the...

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Autori principali: Liu, Chunyan, Zhou, Shaoyu, Begum, Shahnaz, Sidransky, David, Westra, William H., Brock, Malcolm, Califano, Joseph A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890013/
https://ncbi.nlm.nih.gov/pubmed/17118488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2006.10.019
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