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A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain

RNA-interference-driven loss of function in specific tissues in vivo should permit analysis of gene function in temporally and spatially defined contexts. However, delivery of efficient short hairpin RNA (shRNA) to target tissues in vivo remains problematic. Here, we demonstrate that efficiency of p...

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Detalhes bibliográficos
Main Authors: Hassani, Zahra, François, Jean-Christophe, Alfama, Gladys, Dubois, Ghislaine Morvan, Paris, Mathilde, Giovannangeli, Carine, Demeneix, Barbara A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888798/
https://ncbi.nlm.nih.gov/pubmed/17426128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm152
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