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Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice
Increased glycogen synthase kinase-3 (GSK-3) activity is believed to contribute to the etiology of chronic disorders like Alzheimer's disease and diabetes, thus supporting therapeutic potential of GSK-3 inhibitors. However, sustained GSK-3 inhibition might induce tumorigenesis through β-catenin...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1888681/ https://ncbi.nlm.nih.gov/pubmed/17510631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601725 |
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