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Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice

Increased glycogen synthase kinase-3 (GSK-3) activity is believed to contribute to the etiology of chronic disorders like Alzheimer's disease and diabetes, thus supporting therapeutic potential of GSK-3 inhibitors. However, sustained GSK-3 inhibition might induce tumorigenesis through β-catenin...

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Detalhes bibliográficos
Main Authors: Gómez-Sintes, Raquel, Hernández, Félix, Bortolozzi, Analía, Artigas, Francesc, Avila, Jesús, Zaratin, Paola, Gotteland, Jean Pierre, Lucas, José J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888681/
https://ncbi.nlm.nih.gov/pubmed/17510631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601725
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