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Surrogate Light Chain Expressing Human Peripheral B Cells Produce Self-reactive Antibodies

Human B cells that coexpress surrogate and conventional light chains (V-preB(+)L(+)) show an unusual heavy and light chain antibody repertoire that display evidence of receptor editing. However, it is unclear whether V-preB(+)L(+) B cells have been silenced by receptor editing or still express autor...

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Detalhes bibliográficos
Main Authors: Meffre, Eric, Schaefer, Anne, Wardemann, Hedda, Wilson, Patrick, Davis, Eric, Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887722/
https://ncbi.nlm.nih.gov/pubmed/14699083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031550
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